Lucian Msamati ha tenido una extensa carrera que abarca el teatro, el cine, la televisión y la radio. Entre los créditos teatrales de Msamati cabe destacar: Amadeus (National Theatre), Ma Rainey's Black Bottom (National Theatre), A Wolf in Snakeskin Shoes (The Tricycle), Otelo (RSC), Little Revolution (The Almeida), The Amen Corner (National Theatre), If You Don't Let us Dream We Won't Let You A Sleep (Royal Court), Belong (Royal Court), Comedy of Errors (Royal National Theatre), Clybourne Park (Royal Court/West End), Ruined (Almeida Theatre), Death and The Kings Horsman (Royal National Theatre), The Resistabe Rise of Arturo Ui (Lyric Hammersmith), 1807- The First Act (The Globe), Pericles (RSC), The Overwhelming (National Theatre), Walk Hard (Tricycle), Fabulation (Tricycle), Gem Of The Ocean (Tricycle), Who Killed Mr Drum (Riverside), President of An Empty Room (National Theatre), Noche de Reyes (Sheffield Crucible), Mourning Becomes Electra (National, Lyttelton), I.D. (Almeida), Romeo y Julieta (The Dancehouse, Manchester), La fierecilla indomable (Bath Shakespeare Festival), Born African (Arthur Seaton Theatre, New York), Noche de Reyes (Neuss Globe Theatre, Germany), Fade to Black (Harare International Festival of Arts), Eternal Peace Asylum (American Repertory Theatre), Loot, Urfaust (Reps Theatre), Rocky Horror Picture Show (Seven Arts Theatre), and El sueño de una noche de verano (NTO Zimbawbe).

También podemos ver a Msamati en "Gangs Of London", "La materia oscura", "Black Earth Rising", "Kiri", "Electric Dreams" de Philip K Dick", "Taboo", "George Gently", "Luther", "Juego de Tronos”, “Muerte en el Paraíso”, “Ricardo III”, “No.1 Ladies Detective Agency”, “Dr Who”, “Ashes To Ashes”, “Spooks”, “Just Like Ronaldinho”, “Ultimate Force”, “Too Close for Comfort”, “The Knock”, “Heads and Tales”, La gran mentira, The Seekers, The International: Dinero en la sombra, Coffin, Legend of the Sky, Kingdom, Dr Juju, y Lumumba.

Sus créditos en la radio incluyen An Elegy For Easterly, Mugabe: God’s President, The Jero Plays, The Homecoming, Seventh Street, Alchemy, y Colours.

Lucian es miembro fundador de la compañía de teatro Over the Edge en Zimbabue y ex director artístico de Tiata Fahodzi.