- Timothée Chalamet Paul Atreides
- Zendaya Chani
- Rebecca Ferguson Lady Jessica Atreides
- Josh Brolin Gurney Halleck
- Austin Butler Feyd-Rautha Harkonnen
- Florence Pugh Princesa Irulan Corrino
- Dave Bautista Glossu Rabban Harkonnen
- Christopher Walken Emperor Shaddam IV
- Stephen McKinley Henderson Thufir Hawat
- Léa Seydoux Lady Margot
- Stellan Skarsgård Baron Vladimir Harkonnen
- Charlotte Rampling Reverenda Madre Mohiam
- Javier Bardem Stilgar