- Ryan Reynolds Wade Wilson / Deadpool
- Hugh Jackman Logan / Lobezno
- Morena Baccarin Vanessa
- Leslie Uggams Ciego Al
- Aaron Stanford Pyro
- Karan Soni Dopinder
- Matthew MacFadyen Mr. Paradox
- Jennifer Garner Elektra
- Brianna Hildebrand Negasonic Teenage Warhead
- Rob Delaney Peter
- Emma Corrin Cassandra Nova