- Adam Driver Caesar Catalina
- Giancarlo Esposito Alcalde Frank Cicero
- Nathalie Emmanuel Julia Cicero
- Aubrey Plaza Wow Platinum
- Shia Labeouf Clodio Pulcher
- Jon Voight Hamilton Crassus III
- Laurence Fishburne Fundi Romaine
- Kathryn Hunter Teresa Cicero
- Dustin Hoffman Nush 'The Fixer' Berman
- Jason Schwartzman Jason Zanderz
- James Remar Charles Cothope
- D.B. Sweeney Stanley Hart
- Balthazar Getty Aram Kazanjian
- Grace VanderWaal Vesta Sweetwater