- Leonardo DiCaprio Howard Hughes
- Cate Blanchett Katharine Hepburn
- Kate Beckinsale Ava Gardner
- Gwen Stefani Jean Harlow
- Alan Alda Senador Ralph Owen Brewster
- Willem Dafoe Roland Sweet
- Ian Holm Profesor Fitz
- Alec Baldwin Juan Trippe
- John C. Reilly Noah Dietrich
- Jude Law Errol Flynn
- Josie Maran Thelma
- Danny Huston Jack Frye
- Yves Jacques Camarero
- Loudon Wainwright III