- Elizabeth Banks Isabel
- Glenn Close Diana
- James Marsden Jonathan
- Jesse Bradford Alec
- Isabella Rossellini Liz
- Eric Bogosian Henry
- Matthew Davis Mark
- Andrew Howard Ian
- Thomas Lennon Marshall
- John Light Peter
- Susan Malick Rachel
- Michael Murphy Jesse
- Denis O'Hare Andrew
- George Segal Rabino Mendel
- Rufus Wainwright Jeremy
- Ashley Palmer Estudiante
- Jim Parsons Oliver