- Will Smith Alex "Hitch" Hitchens
- Eva Mendes Sara
- Amber Valletta Allegra Cole
- Kevin James Albert
- Michael Rapaport Ben
- Adam Arkin Max
- Julie Ann Emery Casey
- Kevin Sussman Neil
- Jeffrey Donovan Vance
- Paula Patton Mandy
- Philip Bosco Mr. O'Brian
- Beau Sia
- Joe Lo Truglio
- Ato Essandoh Tanis