- Freddie Prinze Jr. Fred Jones
- Sarah Michelle Gellar Daphne Blake
- Matthew Lillard Norville 'Shaggy' Rogers
- Linda Cardellini Velma Dinkley
- Seth Green Patrick Wisely
- Alicia Silverstone Heather Jasper-Howe
- Peter Boyle Jeremiah Wickles
- Tim Blake Nelson Jacobo
- Zahf Paroo Ned
- Kevin Durand Black Knight Ghost
- Karin Konoval Aggie Wilkins