- Bill Murray Steve Zissou
- Cate Blanchett Jane Winslett-Richardson
- Owen Wilson Ned Plimpton
- Anjelica Huston Eleanor Zissou
- Willem Dafoe Klaus Daimler
- Michael Gambon Drakoulias
- Jeff Goldblum Hennessey
- Noah Taylor Wolodarsky
- Bud Cort Bill Ubell
- Seu Jorge Pelé dos Santos
- Robyn Cohen Anne-Marie Sakowitz
- Waris Ahluwalia Vikram Ray
- Niels Koizumi Bobby Ogata
- Pawel Wdowczak Renzo Pietro
- Matthew Gray Gubler
- Eric Chase Anderson Piloto
- Hal Yamanouchi Pirata