- Zach Braff Andrew Largeman
- Natalie Portman Sam
- Ian Holm Gideon Largeman
- Peter Sarsgaard Mark
- Geoffrey Arend Karl Benson
- Ron Leibman Dr. Cohen
- Method Man Diego
- Jean Smart Carol
- Denis O'Hare Albert
- Michael Weston Kenny
- Christopher Carley
- Ann Dowd Olivia
- Jim Parsons Tim
- Ato Essandoh Titembay