- Will Ferrell Ricky Bobby
- Michael Clarke Duncan Lucius Washington
- John C. Reilly Cal Naughton
- Sacha Baron Cohen Jean Girard
- Gary Cole Reese Bobby
- Leslie Bibb Carley Bobby
- David Koechner Herschel
- Ian Roberts Kyle
- Greg Germann Sr. Dennit
- Jane Lynch Madre de Ricky Bobby
- Jack McBrayer Glenn
- Amy Adams Susan
- Andy Richter Gregory
- Molly Shannon Mrs. Dennit
- Elvis Costello El mismo
- Mos Def El mismo
- Ed Lauter John Hannafin
- Rob Riggle Jack Telmont