- Matt Damon Jason Bourne
- Julia Stiles Nicky Parsons
- David Strathairn Noah Vosen
- Scott Glenn Ezra Kramer
- Paddy Considine Simon Ross
- Édgar Ramírez Paz
- Albert Finney Dr. Albert Hirsch
- Joan Allen Pamela Landy
- Chris Cooper Alexander Conklin
- Brian Cox Ward Abbott
- Daniel Brühl John St. Jacques
- Niels Arestrup
- Tom Gallop Tom Cronin
- Scott Adkins Agente Kiley