- Tom Hanks Charlie Wilson
- Julia Roberts Joanne Herring
- Philip Seymour Hoffman Gust Avrakotos
- Amy Adams Bonnie Bach
- Ned Beatty Doc Long
- Om Puri Presidente Zia ul-Hak
- Emily Blunt Jane Liddle
- Cyia Batten Stacy
- Shiri Appleby Jailbait
- Rachel Nichols Suzanne
- John Slattery Henry Cravely
- Wynn Everett Recepcionista
- Mozhan Marnò
- Spencer Garrett
- Navid Negahban
- P.J. Byrne Jim Van Wagenen
- Ken Stott Zvi
- Christopher Denham Mike Vickers
- Joseph Sikora Chess Player
- Nazanin Boniadi
- Pasha D. Lychnikoff Piloto de helicóptero ruso