- Steve Carell Maxwell Smart
- Anne Hathaway Agente 99
- Alan Arkin El jefe
- Terence Stamp Siegfried
- Dwayne Johnson Agente 23
- Terry Crews Agente 91
- David Koechner Larabee
- Bill Murray Agente 13
- Ken Davitian Shtarker
- James Caan El Presidente
- Masi Oka Bruce
- Nate Torrence Lloyd
- Dalip Singh Dalip
- Dimitri Diatchenko Russian Underling
- Jessica Barth
- Mark Ivanir