- Jessica Alba Susan Storm / La Mujer Invisible
- Ioan Gruffudd Reed Richards / Mr. Fantástico
- Chris Evans Johnny Storm / La Antorcha Humana
- Michael Chiklis Ben Grimm / La Cosa
- Julian McMahon Victor Von Doom / Doctor Muerte
- Kerry Washington Alicia Masters
- Andre Braugher General Hager
- Laurence Fishburne Silver Surfer (voz)
- Beau Garrett Frankie Raye
- Doug Jones Silver Surfer
- Brian Posehn
- Stan Lee
- Vanessa Minnillo