- Nicole Kidman Marisa Coulter
- Dakota Blue Richards Lyra Belacqua
- Sam Elliott Lee Scoresby
- Eva Green Serafina Pekkala
- Daniel Craig Lord Asriel
- Tom Courtenay Farder Coram
- Derek Jacobi Emisario Magisterial
- Ben Walker Roger
- Adam Godley Pantalaimon
- Simon McBurney Fra Pavel
- Nonso Anozie Iorek Byrnison
- Jim Carter John Faa
- Clare Higgins Ma Costa
- Jack Shepherd Director de Jordan College
- Magda Szubanski Sra. Lonsdale
- Ian McShane Ragnar Sturlusson
- Charlie Rowe Billy Costa
- Hattie Morahan Sister Clara
- Elliot Cowan