- Ben Stiller Eddie Cantrow
- Michelle Monaghan Miranda
- Malin Akerman Lila
- Rob Corddry Mac
- Jerry Stiller Doc
- Kathy Lamkin Madre de Lila
- Ali Hillis Jodi
- Amy Sloan Deborah
- Carlos Mencia Tito Hernández
- Scott Wilson Boo
- Danny McBride Martin
- Betsy Rue Mimi
- Dean Norris Padre de Jodi
- Dean Norris Collins