- Kathy Baker Bernadette
- Maria Bello Jocelyn
- Emily Blunt Prudie
- Amy Brenneman Sylvia
- Hugh Dancy Grigg
- Maggie Grace Allegra
- Lynn Redgrave Sky
- Jimmy Smits Daniel
- Kevin Zegers Trey
- Parisa Fitz-Henley Corinne
- Gwendoline Yeo Dra. Samantha Yep
- Marc Blucas Dean
- Nancy Travis Cat