- Ben Stiller Tugg Speedman
- Jack Black Jeff Portnoy
- Robert Downey Jr. Kirk Lazarus
- Jay Baruchel Kevin Sandusky
- Steve Coogan Damien Cockburn
- Bill Hader Rob Slolom
- Danny McBride Cody
- Brandon T. Jackson Alpa Chino
- Nick Nolte John "Four Leaf" Tayback
- Reggie Lee Byong
- Brandon Soo Hoo Tran
- Tom Cruise Les Grossman
- Justin Theroux
- Holly Weber
- Tobey Maguire
- Matthew McConaughey
- Mini Anden Secretaria de Grossman