- Dwayne Johnson Jack Bruno
- Annasophia Robb Sara
- Alexander Ludwig Seth
- Carla Gugino Dra. Alex Friedman
- Ciarán Hinds Henry Burke
- Garry Marshall Dr. Donald Harlan
- Tom Everett Scott Matheson
- Chris Marquette Pope
- Billy Brown Carson
- Cheech Marin Eddie
- Kim Richards Tina
- Ike Eisenmann Sheriff Antony
- Omar J. Dorsey Oficial de policía Hough