- Danny DeVito Frank Menure
- Kathy Bates Agnes Menure
- Ron Livingston Dr. Richard Clayton
- Neve Campbell Ellen Minnola
- Bob Odenkirk Mitch Clayton
- Edward Herrmann Doug Clayton
- Christine Baranski Arleen Clayton
- Michael Mckean Ken Hyman
- M.C. Gainey Spicer
- Ed Begley Jr. Sr. Manoire
- Debbi Morgan Sra. Manoire
- Martin Mull Jeffry Morton
- Beverly D'Angelo Angela Minnola