- Rachel McAdams Clare Abshire
- Eric Bana Henry DeTamble
- Arliss Howard Richard DeTamble
- Ron Livingston Gomez
- Stephen Tobolowsky Dr. David Kendrick
- Jane McLean Charisse
- Brooklynn Proulx Clare de joven
- Alex Ferris Henry (6 años)
- Fiona Reid Lucille Abshire