- Isla Fisher Rebecca Bloomwood
- Hugh Dancy Luke Brandon
- Joan Cusack Jane Bloomwood
- John Goodman Graham Bloomwood
- John Lithgow Edgar West
- Kristin Scott Thomas Alette Naylor
- Leslie Bibb Alicia Billington
- Fred Armisen Ryan Koenig
- Julie Hagerty Hayley
- Krysten Ritter Suze Cleath-Stuart
- Robert Stanton Derek Smeath
- Christine Ebersole Martha Lockyear
- Clea Lewis Señorita Ptaszinski
- Wendie Malick Señorita Korch
- Lynn Redgrave
- Stephen Guarino Allon
- Kristen Connolly Girl in Pink