- Paul Rudd Peter Klaven
- Jason Segel Sydney Fife
- Rashida Jones Zooey
- Andy Samberg Robbie
- J.K. Simmons Oz
- Jane Curtin Joyce
- Jon Favreau Barry
- Jaime Pressly Denise
- Mather Zickel Gus
- Thomas Lennon Doug
- Aziz Ansari Eugene
- Joe Lo Truglio Lonnie
- Rob Huebel Tevin Downey
- Nelson Franklin Sydney's Buddy
- Carla Gallo Amiga de Zooey
- Melissa Rauch Woman Jogger Yelling at Sydney
- Nick Kroll Larry