- Johnny Depp Barnabas Collins
- Eva Green Angelique Bouchard
- Michelle Pfeiffer Elizabeth Collins Stoddard
- Jonny Lee Miller Roger Collins
- Helena Bonham Carter Dr. Julia Hoffman
- Chloë Grace Moretz Carolyn Stoddard
- Jackie Earle Haley Willie Loomis
- Bella Heathcote Victoria Winters / Josette duPres
- Gulliver McGrath David Collins
- Christopher Lee Clarney
- David Selby Invitado
- Sophie Kennedy Clark Hippie Chick 1
- Sean Mahon Policía
- Hannah Murray Hippie Chick 2