- Meryl Streep Jane Adler
- Alec Baldwin Jake Adler
- Steve Martin Adam
- Lake Bell Agness
- John Krasinski Harley
- Caitlin Fitzgerald Lauren
- Zoe Kazan Gabby
- Hunter Parrish Luke
- Rita Wilson Trisha
- Mary Kay Place Joanne
- Alexandra Wentworth Diane
- Nora Dunn Sally
- Daryl Sabara Edward
- Emjay Anthony Pedro Adler