- Jack Black Lemuel Gulliver
- Emily Blunt Princesa María
- Jason Segel Horacio
- Amanda Peet Darcy
- Billy Connolly Rey Teodoro
- Chris O'Dowd Edward
- T.J. Miller Dan
- James Corden Jinks
- Catherine Tate Reina Isabel
- Romany Malco Joven Hank
- Emmanuel Quatra Rey Leopoldo
- Joe Lo Truglio Butt-crack Man
- Olly Alexander Prince August
- Gemma Whelan Lilliputian Rose