- Jennifer Aniston Nicole Hurley
- Gerard Butler Milo Boyd
- Christine Baranski Kitty Hurley
- Jason Sudeikis Stewart
- Siobhan Fallon Hogan Teresa
- Cathy Moriarty-Gentile Irene
- Dorian Missick Bobby
- Joel Garland Dwight
- Matt Malloy Gary
- Peter Greene Mahler
- Jeff Garlin Sid
- David Costabile Arthur