- Brendan Fraser Dan Sanders
- Brooke Shields Tammy Sanders
- Ken Jeong Neal Lyman
- Angela Kinsey Felder
- Wallace Shawn Dr. Burr
- Samantha Bee Principal Baker
- Matt Prokop Tyler Sanders
- Skyler Samuels Amber
- Jim Norton Hank
- Alice Drummond Sra. Martin
- Rob Riggle Riggs
- Eugene Cordero Cheese
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