- Tom Cruise Ethan Hunt
- Jeremy Renner William Brandt
- Simon Pegg Benji Dunn
- Paula Patton Jane Carter
- Michael Nyqvist Kurt Hendricks
- Vladimir Mashkov Anatoly Sidirov
- Josh Holloway Trevor Hanaway
- Anil Kapoor Brij Nath
- Léa Seydoux Sabine Moreau
- Tom Wilkinson Secretario del IMF
- Samuli Edelmann
- Ving Rhames Luther Stickell