- Katherine Heigl Holly Berenson
- Josh Duhamel Eric Messer
- Christina Hendricks Alison Novack
- Josh Lucas Sam
- Jean Smart Helen Berenson
- Melissa McCarthy DeeDee
- Faizon Love Walter
- Hayes MacArthur Peter
- Andrew Daly Scott
- Reggie Lee Alan Burke
- DeRay Davis Lonnie
- Rob Huebel Ted
- Will Sasso Josh
- Kumail Nanjiani Simon