- James McAvoy Frederick Aiken
- Robin Wright Mary Surratt
- Kevin Kline Edwin Stanton
- Tom Wilkinson Reverdy Johnson
- Evan Rachel Wood Anna Surrat
- Justin Long Nicholas Baker
- Danny Huston Joseph Holt
- James Badge Dale William Hamilton
- Colm Meaney David Hunter
- Alexis Bledel Sarah Weston
- Johnny Simmons John Surrat
- Toby Kebbell John Wilkes Booth
- Jonathan Groff Louis Weichmann
- Stephen Root John Lloyd