- Tom Hanks Larry Crowne
- Julia Roberts Mercedes Tainot
- Bryan Cranston Dean Tainot
- Cedric the Entertainer Lamar
- Taraji P. Henson B'Ella
- Gugu Mbatha-Raw Talia
- Wilmer Valderrama Dell Gordo
- Pam Grier Frances
- Rami Malek Steve Dibiasi
- Holmes Osborne Dave Busik
- Rob Riggle Jack Strang
- Jon Seda
- Randall Park Trainee Wong
- Grace Gummer Natalie Calimeris
- George Takei Dr. Matsutani