- Nicolas Cage Charlie Kaufman / Donald Kaufman
- Meryl Streep Susan Orlean
- Chris Cooper John Laroche
- Tilda Swinton Valerie
- Maggie Gyllenhaal Caroline
- Cara Seymour
- Brian Cox Robert McKee
- Judy Greer
- Ron Livingston
- Jay Tavare
- Gregory Itzin
- Jim Beaver Ranger Tony