- Garrett Hedlund Dean Moriarty / Neal Cassady
- Sam Riley Sal Paradise / Jack Kerouac
- Kristen Stewart Marylou / LuAnne Henderson
- Amy Adams Jane / Joan Vollmer
- Tom Sturridge Carlo Marx / Allen Ginsberg
- Alice Braga Terry / Bea Franco
- Kirsten Dunst Camille / Carolyn Cassady
- Viggo Mortensen Old Bull Lee / William S. Burroughs
- Elisabeth Moss Galatea Dunkle / Helen Hinkle
- Madison Wolfe Dodie Lee (8)