- Jason Biggs Jim
- Alyson Hannigan Michelle Flaherty-Levenstein
- Chris Klein Oz
- Thomas Ian Nicholas Kevin Myers
- Tara Reid Vicky Lathum
- Seann William Scott Stifler
- Mena Suvari Heather
- Eddie Kaye Thomas Finch
- Jennifer Coolidge Madre de Stifler
- Eugene Levy Padre de Jim
- Katrina Bowden Mia
- Shannon Elizabeth Nadia
- Dania Ramirez Selena
- Natasha Lyonne Jessica
- Chris Owen Shermanator
- John Cho
- Neil Patrick Harris
- Vik Sahay Prateek Duraiswamy
- Vince Pisani Male Alum
- Charlene Amoia Ellie