- Tyler Perry Dr. Alex Cross
- Matthew Fox Picasso
- Edward Burns Tommy Kane
- Rachel Nichols Monica Ashe
- Jean Reno Giles Mercier
- Carmen Ejogo Maria Cross
- John C. McGinley Richard Brookwell
- Yara Shahidi Janelle Cross
- Cicely Tyson Nana Mama
- Chad Lindberg Vincent Dardis
- Stephanie Jacobsen Fan Yau
- Giancarlo Esposito Daramus Holiday