- Chiwetel Ejiofor Solomon Northup
- Michael Fassbender Edwin Epps
- Benedict Cumberbatch Ford
- Paul Dano Tibeats
- Garret Dillahunt Armsby
- Paul Giamatti Freeman
- Scoot McNairy Brown
- Sarah Paulson Señora Epps
- Brad Pitt Bass
- Michael Kenneth Williams Robert
- Alfre Woodard Señora Shaw
- Ruth Negga Celeste
- Bill Camp Ebenezer Radburn
- Marcus Lyle Brown Jasper
- Lupita Nyong'o Patsey
- Adepero Oduye Eliza
- Quvenzhané Wallis Margaret Northup
- Dwight Henry Tío Abram
- Kelvin Harrison Jr. Víctima 2
- Chris Chalk Clemens
- Storm Reid Emily
- Taran Killam Hamilton
- Jay Huguley Sheriff