- Tom Cruise Teniente Coronel Bill Cage
- Emily Blunt Rita Vrataski
- Bill Paxton General Farrell
- Brendan Gleeson General Brigham
- Kick Gurry Griff
- Charlotte Riley Nance
- Masayoshi Haneda Takeda
- Noah Taylor Dr. Carter
- Terence Maynard Cruel Sergeant
- Jonas Armstrong Skinner
- Tony Way Kimmel
- Franz Drameh Ford
- Dragomir Mrsic Kuntz
- Lara Pulver Karen Lord
- Matt Hookings