- Benedict Cumberbatch Khan
- Karl Urban Dr. Leonard McCoy
- Chris Pine Capitán James T. Kirk
- Zoe Saldana Nyota Uhura
- Alice Eve Dr. Carol Marcus
- Simon Pegg Scotty
- Zachary Quinto Spock
- Anton Yelchin Pavel Chekov
- Bruce Greenwood Capitán Pike
- John Cho Hikaru Sulu
- Peter Weller Almirante de la Flota Estelar
- Cynthia Addai-Robinson Mujer San Francisco
- Joseph Gatt Science Officer 0718
- Ser'Darius Blain U.S.S. Enterprise Red Shirt