- Will Ferrell Brad
- Mark Wahlberg Dusty
- Linda Cardellini Sarah
- Thomas Haden Church Leo
- Bobby Cannavale Dr. Francisco
- Alessandra Ambrosio Karen
- Owen Vaccaro Dylan
- Scarlett Estevez Megan
- Hannibal Buress Griff
- Paul Scheer The Whip (Arena Radio DJ)
- Didi Costine Hijastra de Dusty