- Diane Keaton Charlotte
- John Goodman Sam
- Ed Helms Hank
- Alex Borstein Angie
- Timothée Chalamet Charlie
- Amanda Seyfried Ruby
- Alan Arkin Bucky
- Marisa Tomei Emma
- Olivia Wilde Eleanor
- Anthony Mackie Oficial Williams
- June Squibb Tía Fishy
- Jon Tenney Dr. Morrissey
- Jake Lacy Joe
- Molly Gordon Lauren Hesselberg