- Matt Damon Mark Watney
- Jessica Chastain Comandante Lewis
- Chiwetel Ejiofor Dr. Vincent Kapoor
- Kristen Wiig Annie Montrose
- Jeff Daniels Teddy Sanders
- Michael Peña Rick Martinez
- Kate Mara Beth Johanssen
- Sean Bean Mitch Henderson
- Sebastian Stan Chris Beck
- Aksel Hennie Alex Vogel
- Donald Glover Rich Purnell
- Mackenzie Davis Mindy Park