- Nia Vardalos Toula
- John Corbett Ian
- Michael Constantine Gus
- Lainie Kazan Maria
- Andrea Martin Tía Voula
- Gia Carides Nikki
- Joey Fatone Angelo
- Elena Kampouris Paris
- Louis Mandylor Nick
- John Stamos George
- Rita Wilson Anna
- Mark Margolis Panos
- Ian Gomez Mike
- Alex Wolff Bennett
- Bess Meisler Mana-Yiayia
- Bruce Gray Rodney Miller
- Fiona Reid Harriet Miller
- Jayne Eastwood Sra. White