- Samuel L. Jackson Mayor Warren
- Kurt Russell John Ruth
- Jennifer Jason Leigh Daisy Domergue
- Walton Goggins Chris Mannix
- Michael Madsen Joe Gage
- Tim Roth Oswaldo Mobray
- Demián Bichir Bob el Mexicano
- Bruce Dern General Smithers
- Channing Tatum Jody
- Zoë Bell Six-Horse Judy