- Seth Rogen Mac Radner
- Zac Efron Teddy Sanders
- Rose Byrne Kelly Radner
- Chloë Grace Moretz Shelby
- Dave Franco Pete
- Ike Barinholtz Jimmy
- Carla Gallo Paula
- Christopher Mintz-Plasse Scoonie
- Kiersey Clemons Beth
- Beanie Feldstein Nora
- Lisa Kudrow Decana Carol Gladstone
- Selena Gomez Presidenta Phi Lamda
- Sam Richardson Eric Baiers
- Abbi Jacobson Jessica Baiers
- Awkwafina Christine
- Billy Eichner Oliver Studebaker