- Al Pacino Danny Collins
- Annette Bening Mary Sinclair
- Jennifer Garner Samantha Leigh Donnelly
- Bobby Cannavale Tom Donnelly
- Christopher Plummer Frank Grubman
- Melissa Benoist Jamie
- Josh Peck Nicky Ernst
- Scott Lawrence Dr. Ryan Kurtz
- Nick Offerman Guy DeLoach
- Tim Jo Tim
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