- Taraji P. Henson Katherine Johnson
- Octavia Spencer Dorothy Vaughn
- Janelle Monáe Mary Jackson
- Kevin Costner Al Harrison
- Mahershala Ali Jim Johnson
- Jim Parsons Paul Stafford
- Kimberly Quinn Ruth
- Kirsten Dunst Vivian Mitchell
- Glen Powell John Glenn
- Aldis Hodge Levi Jackson
- Frank Hoyt Taylor Juez
- Karan Kendrick Joylette Coleman (joven)
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