- Anthony Hopkins Dr. John Clancy
- Colin Farrell Charles Ambrose
- Jeffrey Dean Morgan Agente Joe Merriwether
- Abbie Cornish Agente especial del FBI Katherine Cowles
- Matt Gerald Agente Sloman
- Jose Pablo Cantillo Agente Sawyer
- Marley Shelton Laura Merriwether
- Xander Berkeley Sr. Ellis
- Joshua Close Linus Harp