- Margo Martindale Sally Hollar
- Sharlto Copley Ron Hollar
- Richard Jenkins Don Hollar
- John Krasinski John Hollar
- Anna Kendrick Rebecca
- Randall Park Dr. Fong
- Josh Groban Reverendo Dan
- Charlie Day Jason
- Mary Kay Place Pam
- Mary Elizabeth Winstead Gwen
- Didi Costine Matilda